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Brisket Mac and Cheese casserole in a white baking dish. A black spoon scoops out a creamy portion, showcasing the elbow macaroni, chunks of brisket, and a golden, bubbly baked cheese topping.

Brisket Mac and Cheese: How to Make It Perfect Every Time

By Nancy
Want bold flavor in every bite? Brisket Mac and Cheese brings together rich cheddar and juicy beef. Discover the easy recipe now.
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Prep Time 20 minutes
Cook Time 1 hour 10 minutes
Total Time 1 hour 30 minutes
Course main dish
Cuisine American, Southern-inspired
Servings 8
Calories 780 kcal

Ingredients
  

  • Cooked brisket chopped or shredded
  • Elbow macaroni or any short pasta
  • Sharp cheddar cheese
  • Gruyère or Monterey Jack
  • Butter
  • Flour
  • Whole milk or half-and-half
  • Paprika garlic powder, black pepper
  • Panko or crushed Ritz crackers optional
  • BBQ sauce optional

Instructions
 

Step 1: Cook the Pasta

  • Boil salted water and cook your pasta until just al dente

Step 2: Warm the Brisket

  • Cut or slice the brisket into strips and gently warm it in a skillet. A little broth will keep it moist. If you're using smoked brisket

Step 3: Build the Roux

  • Melt butter in a pot, whisk in the flour, and cook for a minute until golden.

Step 4: Add the Milk

  • Slowly pour in the milk while whisking. The sauce thickens in a couple of minutes.

Step 5: Melt the Cheese

  • Reduce heat and add cheddar and Gruyère. Stir until melted, silky, and glossy.

Step 6: Season with Intention

  • Add paprika, garlic powder, pepper, and salt only if needed. Brisket brings saltiness,

Step 7: Combine Everything

  • Stir the pasta into the cheese sauce. Fold in the brisket. The mixture becomes thick, luxurious

Step 8: Add the Topping

  • Pour into a skillet. Sprinkle panko or crushed crackers mixed with a bit of melted butter.

Step 9: Bake

  • Bake at 350°F (175°C) for 20–25 minutes until bubbling. The edges brown and crisp.

Notes

Nutritional Information

  • Calories: 780
  • Protein: 31g
  • Carbs: 58g
  • Fat: 42g
  • Sodium: 820mg
  • Fiber: 2g
Keyword Brisket Mac and Cheese